#6294 UTILITY OF KIDNEY BIOPSY AND SPECTRUM OF BIOPSY PROVEN KIDNEY DISEASES IN PATIENTS WITH MALIGNANCY: A RETROSPECTIVE SINGLE-CENTER EXPERIENCE

Abstract Background and Aims Kidney biopsy may improve diagnostic accuracy aid in the management of cancer patients with kidney diseases. However, literature on utility survivors is lacking. We aimed to evaluate clinical characteristics who underwent biopsy, as well histological spectrum proven diseases this cohort. Method This was a single-center retrospective study all had native biopsies at Singapore General Hospital between 1st October 2015 31st December 2022. Demographic, clinical, laboratory data were retrieved from electronic medical records identify solid-organ or hematological malignancies biopsy. Results Out 1208 2022, 116 (9.6%) diagnoses malignancies. Approximately two-thirds (79/116; 68.1%) malignancies, which 21.5% metastatic disease time one-third (36/116; 31.0%) 10 (8.6%) stem-cell transplant (HSCT). One (0.9%) patient both Sixty-eight (58.6%) remission comprising 52 (44.8%) 16 (13.8%) solid -organ respectively. Median age 65.7 years (IQR 56.5, 71.4) majority female (61/116; 52.6%). Comorbidities hypertension, type 2 diabetes mellitus, autoimmunity, liver found 36.2% (42/116), 23.3% (27/116), 8.6% (10/116) 1.7% (2/116) serum creatinine 152.0μmol/L 101.8, 220.5). Micro-hematuria present approximately (68.1%) patients. Nephrotic range proteinuria nephrotic syndrome observed one-quarter (25.9%) (31.0%) patients, half (49.1%) acute injury while one-fifth (19.8%) progressive chronic disease. A wide observed. Glomerulonephritides, tubulointerstitial inflammation and/or glomerular endothelial injuries diagnosed 60.8% (48/79) 80.6% (29/37) Amongst active (n = 20), nephritis (ATIN) (5/20, 25.0%), IgA nephropathy (3/20; 15.0%) lupus most common primary diagnoses. 17), dysproteinemic leukemic infiltration frequently (6/17; 35.9%). Compared status, malignancy not associated an increased likelihood overall diagnosis glomerulonephritides, (p 0.16). Specifically, incidence membranous similar those 0.42). HSCT, thrombotic microangiopathy (40.0%) frequently. Overall, onco-therapeutics-related 13 (11.2%) ATIN (38.4%) commonly encountered, followed by (30.7%). Conclusion provides valuable information amongst While broad can be observed, remain common.